This animation describes the structure, properties, and uses of the spherical nucleic acid (SNA), a construct typically composed of a nanoparticle core and densely packed and highly oriented nucleic acid shell. This structure has unique architectural-dependent properties that set it apart from all other forms of nucleic acids. These properties make SNAs extremely useful in in vitro medical diagnostics, intracellular detection, and therapeutics.
Spherical Nucleic Acids (SNAs) were developed in the laboratory of Professor Chad A. Mirkin at Northwestern University under the auspices of the International Institute for Nanotechnology (IIN).
This research is supported by the Air Force Office of Scientific Research, Defense Advanced Research Projects Agency, National Institutes of Health, National Cancer Institute, and the National Science Foundation.